eigen-reprod-atlas — paper drafts

Open the public lab notebook

The current canonical site is under /eigen-reprod-atlas/. It distinguishes engineering smoke evidence from future biological benchmark claims.

Auditable local SimpleFold-3B inference on Apple Silicon: an 8-target reproducibility benchmark.
Author: Raúl Chío León¹·²
¹ Eigen Biotech (umbrella) · ² Tecnológico de Monterrey, Campus Guadalajara, Mexico

Status — 2026-05-18: Phase 1A complete. SimpleFold-3B produced predictions and scores for all 8 frozen targets on the M3 Max; the paper now includes a Claim/Evidence/Limitation table, target-set rationale, selective repeat controls, and scorer documentation.
Phase 0 public-tunnel results (3 engineering targets, SimpleFold-100M, MLX on M3 Max)
TargetaalDDTTM-scoreRMSDWall (s)
1L2Y Trp-cage200.97080.67390.39 Å112.86
1CRN crambin460.98670.97380.35 Å111.36
1UBQ ubiquitin760.96500.96590.81 Å110.86
Median0.97080.96590.39 Å111.36

Durable Object audit count: 41 entries. Public result packet: phase0-public-tunnel-smoke.

v1 Workshop paper draft

Living IMRaD draft with Phase 0 validation, completed Phase 1A SimpleFold-3B evidence, and conservative scientific boundaries.

Target venues: NeurIPS ML4H 2026 · ICLR ML4Science 2027 · bioRxiv preprint

Abstract draft

Living abstract v0.7: bounded SimpleFold-3B Apple Silicon claim with explicit non-claims, public source release, and Zenodo DOI.

Second committee response

Tracked response to the latest Weak Accept / Major Revision light critique.

Repository

github.com/Theovia/eigen-reprod-atlas (private during build phase)

Phase 0 findings doc, full architecture, MCP server source, M3 Max bridge, agent prompts.

Last updated: 2026-05-13 · Auto-refresh on deploy